Better together. For life.

PhD position in Molecular Immunology (Basic Science research project)


Doktorandenstelle in Molekularer Immunologie (Grundlagenforschungsprojekt) (w/m/d)

Part-time| Location: Hamburg-Eppendorf| General Surgury Laboratory, UKE, AG Gagliani

At the UKE, we are convinced that successful and fulfilling work should be harmonised with the personal needs and individual life plans of all employees. Together we can make this possible.

Every day a little more. Every day a little better.

What to expect

We are the UKE – the University Medical Centre Hamburg-Eppendorf [Universitätsklinikum Hamburg-Eppendorf]. A pulsating centre of health in the heart of Hamburg. When you are surrounded by that much energy and when progress sets the pace, no two days are the same. More than 14,100 employees with very different responsibilities are united by the same goal: ensuring health and well-being.

CD4+ TH17 cells underlie autoimmune diseases such as Multiple Sclerosis (MS) and Inflammatory Bowel disease (IBD) and have important roles in homeostasis and inflammation. How TH17 cells balance their pathogenic and regulatory functions is not understood. Upon their TCR engagement and co-stimulation, the CD4+ TH17 cells proliferate and remodel their metabolism to acquire TH17 steady state effector and/or pathogenic functions. Furthermore, during the resolution of the inflammatory response, TH17 cells finally convert into anti-inflammatory TR1 cells. How the metabolic switch to pathogenic TH17 cells is controlled is currently unkown but nevertheless, the identification of the gatekeeping mechanisms of TH17 cell pathogenicity portends immense therapeutic potential in autoimmunity.

Blimp1 (the product of PrdmI gene) is a terminal differentiation transcription factor for many cell types, including B and T lymphocytes, while its role in CD4+ TH17 cells remains controversial. To address the conundrum, we have conditionally deleted Prdm1 specifically in TH17 cells, in the context of a mouse model allowing us to follow in real time, the in vivo fate of the Blimp1-deficient TH17 cells. Our data indicate that Blimp1 controls both the pathogenic and regulatory fate of TH17 cells via a yet unidentified switch to their basic metabolic program.

This work program specifically addresses this hypothesis, aiming to shed light into the molecular principle(s) controlling the pathogenic TH17 cell metabolism and identify new therapeutic targets in autoimmunity.

  • Fully funded research project
  • Project supervision from a Molecular Biology and Epigenetics Scientist
  • Integration into a small project related team with close supervision and mentoring
  • Overall integration in a highly collaborative working environment of three working groups
  • Weekly discussion and feedback rounds with supervisors
  • Possibility to work on an established project with state-of-the-art experimental techniques
  • Integration into structured institutional PhD program

This position is temporary for 3 years.

What we look forward to

  • Completed academic studies in biology, biochemistry, human biology, bioinformatics or related subjects
  • Basic knowledge in basic biological methods and cell culture
  • Basic knowledge in either epigenetics, immunology or metabolism
  • Basic knowledge in bioinformatic analysis of multi-omic data and/or work with laboratory mice
  • High degree of intrinsic motivation and an aptitude for problem solving

What we can offer

  • International and multidisciplinary environment at a leading European Institution, the University Medical Center Hamburg-Eppendorf (Germany)
  • Access to several sophisticated mouse models (germ-free mice, Inflammatory-mediated Immune Disease models, immune cell reporter mice), multi-omics (single-cell sequencing; metabolomic screening; proteomics) along with direct access to human material for potential translational studies
  • A Molecular Biology Scientific project in the fields of the Epigenetic and Metabolomic aspects of Immune-mediated Inflammatory diseases
  • A FELASA A introductory course for animal experimentation
  • A personal, step-by-step introduction and coaching to a variety of state-of-the-Art Molecular Biology, Immunology and Metabolomics methods, animal husbandry and in vivo mouse model experimentation.
  • Weekly scientific exchange: lab meetings and journal clubs
  • International collaboration with partners in European and American Academic Institutions (USA)
  • Access to the soft skills programme of the institution: e.g., presenting skills, scientific writing

The UKE

We are the UKE - and we stand for excellent competence in the areas of research, teaching and comprehensive health care in our clinics. Every day our 14.100 employees strive to make the world a little healthier by their contribution.

It is our aim to be one of the leading University Medical Centers and, at the same time, the best employer in our industry. At the UKE, we are convinced that successful and fulfilling work should be harmonised with the personal needs and individual life plans of all employees. And as different as these are, as diverse is our range of individual solutions.

Better together. For life.
Welcome to the UKE.


> Find out more about the UKE and our aspirations as an employer

Your application options at a glance

Choose the application method that suits you best.
You can send us your application quickly and easily - online, by email or by post. Alternatively, you can submit your application to our recruiting team in person.
> Click here to access information on the various application options

We live and value diversity
We offer a work environment providing equal opportunities regardless of age, gender, sexual identity, disability, origin or religion. This is affirmed by our accession to the Charter of Diversity.

We explicitly strive to increase the proportion of women in management positions, especially among scientific staff in research and teaching.

The same applies in case of an underrepresentation of one's gender in the advertising area. People with severe disabilities will be considered with priority in case of equal suitability, qualification and professional performance.
> Find out more about diversity at the UKE

Your Perspective

Hamburg and its UKE. As one of the largest employers in the Hanseatic city, we stand for excellent competence in the areas of research, teaching and comprehensive health care in our clinics. Every day our 14.100 employees strive to make the world a little healthier by their contribution.

With more than 140 different job profiles – in nursing, the various healthcare professions, in medical and medical-technical services or therapeutic and educational professions as well as in research and teaching up to a career in administration or in the technology and service area – we are the ideal place for everyone who wants to keep getting better with us.

Better together. For life.
Welcome to the UKE.


> Find out more about the different professions and prospects at the UKE here

Contact

Ms Dana Klatt, e-mail: d.klatt@uke.de // Dr Theodora Agalioti, email: t.agalioti@uke.de

Please note that your application can only be considered if you are fully immunised against the SARS-CoV-2 virus (at the latest at the start of engagement), supported by valid official vaccination certificate(s). Please submit these with your application

We look forward to receiving your complete application by 26.08.2022 stating reference code WS22603_engl.

Apply now for the advertised position from the University Medical Center Hamburg-Eppendorf (UKE). Better together. For life.
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