Better together. For life.

Postdoc for Internal Medicine


Postdoc for Internal Medicine

Fulltime/part-time| Location: Hamburg-Eppendorf| Center for Internal Medicine – I. Department of Medicine and Polyclinic| Section of Immunology and Gastroenterology

At the UKE, we are convinced that successful and fulfilling work should be harmonised with the personal needs and individual life plans of all employees. Together we can make this possible.

Every day a little more. Every day a little better.

What to expect

We are the UKE – the University Medical Centre Hamburg-Eppendorf [Universitätsklinikum Hamburg-Eppendorf]. A pulsating centre of health in the heart of Hamburg. When you are surrounded by that much energy and when progress sets the pace, no two days are the same. More than 14,400 employees with very different responsibilities are united by the same goal: ensuring health and well-being.

A Postdoctoral position is available in the laboratory of Samuel Huber (ERC funded) at the University Medical Centre Hamburg-Eppendorf (UKE), home to a modern and vibrant healthcare community right in the heart of Hamburg. There is a real buzz of energy here, as progress sets the pace and every day offers fresh experiences. Around 11,000 members of staff with a huge diversity of roles are united in pursuit of a single aim: human wellbeing.

With more than 140 different professions, we are the ideal place for anyone who loves to work in an innovative and flexible working environment, and for anyone with the ambition to advance their own personal development and that of healthcare as a whole. We are looking for highly motivated candidates with a strong interest in basic and translational Immunology

Overall goal of the Lab

Inflammation is fundamental in promoting tissue regeneration upon injury, which is then essential in resolving immune response. Physiological tissue regeneration depends on a finely tuned interaction between the immune system, the tissue, and the microbiota. However, the complex interaction between these three components and the molecules that mediate the communication are unclear. This is particularly important at mucosal surfaces, where continuous regeneration occurs. The central hypothesis of our laboratory is that inflammatory bowel disease (IBD) and colorectal cancer (CRC) are a result of miscommunication between these components (Huber, et al., Nature, 2012; Gagliani, et al., Cell, 2014; Gagliani, et. al., Nature, 2015; Pelzcar, et al., Science, 2016; Brockmann, et al., Nat. Commun. 2018). Our aim is to understand how the complex interactions between the immune system (with a focus on CD4+ T helper cells and their cytokine products), the tissue, and the microbiota lead to either physiological or pathological tissue regeneration. To achieve this, we developed an integrated platform to combine in vitro and in vivo functional experiments using mouse models and human tissue samples with next generation sequencing at bulk and at single-cell level, including CITE-Seq, TCR-Seq and ATAC-Seq. This provides the basis to define the molecular mechanisms regulating inflammation and tissue regeneration at the bulk and single-cell level. In addition, we use a Systems Biology/Immunology approach to identify how the intestinal immune regulation can control intestinal and systemic immune responses. This will provide the basis for new therapies for immune-mediated inflammatory diseases and cancer.

What we look forward to

  • Completed academic university degree in biology, biochemistry, human biology, human medicine, nutrition, or in a related subject
  • Experience with murine disease models, cell and molecular biological methods
  • Ideally experience with flow cytometry and FlowJo
  • Experience with MS Office and Prism
  • Excellent spoken and written English skills
  • Responsible, careful, structured and solution-oriented way of working
  • Organizational skills, fast and willing to learn, flexible, assertive and team work

What we can offer

  • The research project is in the field of immunology and nutrition with a focus on inflammation, wound healing and microbiome. As part of the EU-funded project miGut-Health (Horizon Europe 2022), a proof-of-concept human study will be implemented to investigate the influence of gluten-free dietary/nutrition associated factors on inflammation development and reduction linked to gut inflammation will be assessed.
  • Planning and implementation of complex in vitro and in vivo experiments
  • Data evaluation and authorship of scientific publications
  • Involvement in grant applications
  • Supervision and guidance of students, interns and other academic staff (BTA, MTA, study nurse etc.)
  • Fulfilling research tasks
  • Collection and documentation of research results

The UKE

We are the UKE - and we stand for excellent competence in the areas of research, teaching and comprehensive health care in our clinics. Every day our 14.400 employees strive to make the world a little healthier by their contribution.

It is our aim to be one of the leading University Medical Centers and, at the same time, the best employer in our industry. At the UKE, we are convinced that successful and fulfilling work should be harmonised with the personal needs and individual life plans of all employees. And as different as these are, as diverse is our range of individual solutions.

Better together. For life.
Welcome to the UKE.


> Find out more about the UKE and our aspirations as an employer

Your application options at a glance

Choose the application method that suits you best.
You can send us your application quickly and easily - online, by email or by post. Alternatively, you can submit your application to our recruiting team in person.
> Click here to access information on the various application options

We live and value diversity
We offer a work environment providing equal opportunities regardless of age, gender, sexual identity, disability, origin or religion. This is affirmed by our accession to the Charter of Diversity.

We explicitly strive to increase the proportion of women in management positions, especially among scientific staff in research and teaching.

The same applies in case of an underrepresentation of one's gender in the advertising area. People with severe disabilities will be considered with priority in case of equal suitability, qualification and professional performance.
> Find out more about diversity at the UKE

Your Perspective

Hamburg and its UKE. As one of the largest employers in the Hanseatic city, we stand for excellent competence in the areas of research, teaching and comprehensive health care in our clinics. Every day our 14.100 employees strive to make the world a little healthier by their contribution.

With more than 140 different job profiles – in nursing, the various healthcare professions, in medical and medical-technical services or therapeutic and educational professions as well as in research and teaching up to a career in administration or in the technology and service area – we are the ideal place for everyone who wants to keep getting better with us.

Better together. For life.
Welcome to the UKE.


> Find out more about the different professions and prospects at the UKE here

Contact

Contact: Dr. med. Sina Hübener, e-mail: s.huebener@uke.de

Please note that your application can only be considered if you are fully immunised against the SARS-CoV-2 virus (at the latest at the start of engagement), supported by valid official vaccination certificate(s). Please submit these with your application.

We look forward to receiving your complete application by 19.12.2022 stating reference code WS22926_engl.

Please apply via BEWERBUNG@UKE.DE

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