Better together. For life.

Doctoral Researcher (f/m/d) in the field of Helminth-induced suppression of vaccine responses (Systems Vaccinology)


Doctoral Researcher (f/m/d) in the field of Helminth-induced suppression of vaccine responses (Systems Vaccinology)

part-time| Location: Hamburg-Eppendorf| Zentrum für Innere Medizin – Institut für Infektionsforschung und Impfstoffentwicklung

At the UKE, we are convinced that successful and fulfilling work should be harmonised with the personal needs and individual life plans of all employees. Together we can make this possible.

Every day a little more. Every day a little better.

What to expect

We are the UKE – the University Medical Centre Hamburg-Eppendorf [Universitätsklinikum Hamburg-Eppendorf]. A pulsating centre of health in the heart of Hamburg. When you are surrounded by that much energy and when progress sets the pace, no two days are the same. More than 14,100 employees with very different responsibilities are united by the same goal: ensuring health and well-being.

The UKE offers the opportunity to perform cutting-edge research in an excellent research environment. The Institute for Infection Research and Vaccine Development (IIRVD, webpage: https://www.uke.de/kliniken-institute/institute/infektionsforschung-und-impfstoffentwicklung/team/index.html ) (Director: Prof. Dr. Marylyn Addo) focuses on the development of novel vaccines against emerging viruses. Within the Institute, we use Systems Vaccinology approaches enabling a comprehensive insight into vaccine-induced immune responses and mechanisms leading to vaccine efficacy or failure. This approach combines multiple omics technologies to collect data on e.g. transcriptomic changes, microRNA dynamics and changes of immune cells and signalling molecules before and after vaccination. Data sets are combined in a computational approach to understand the mechanisms of protective immunity and to identify markers of early innate immune responses that may predict the outcome of vaccination.

The overall goal of this DFG-funded project is to investigate the mechanisms involved in different vaccine responses using a systems vaccinology approach in a murine model. This project is based on a collaboration between the UKE and the Bernhard-Nocht-Institute of Tropical Medicine (BNITM, https://www.bnitm.de/ ) joining two expertises. The AG Helminth Immunology (BNITM) uses a murine model for human helminth infections. The aim of the proposed study is to better understand how helminth infections influence vaccine-induced responses and vaccine efficacy since extrinsic factors, like pre-existing helminth infections, can dampen the immune response and thereby impair vaccine efficacy.

This project aims to combine the expertise of both research groups at UKE and BNITM, applying Systems Vaccinology to the well-established mouse model of helminth-induced suppression of vaccine responses. A broader knowledge of mechanisms underlying vaccine efficacy and failure might contribute to future vaccine development strategies that reduce vaccine failure in the context of a helminth infection.

The position is to be filled initially by a fixed-term employment for three years and the salary will be according to 65% EG 13 TVöD. The starting date is the beginning of November 2022 or later.

What we look forward to

  • Highly motivated candidate with a strong interest in basic immunology and vaccinology
  • Master degree in molecular life sciences, biology, immunology or a relevant field
  • Basic knowledge of multicolor flow cytometry
  • Basic knowledge of RNA Sequencing
  • Willingness to carry out infection experiments in the mouse system; FELASA B is an advantage but not mandatory
  • Willingness to learn and develop new methods to evaluate innate immune responses on multiple level (RNA, DNA, protein) and with various techniques (PBMC isolation, cell culture, flow cytometry, sequencing approaches)
  • Motivated to learn novel data analyses (R, flowjo, Prism)
  • Independent, creative and self-reliant working style
  • Very good knowledge of English (written and spoken) due to the international orientation of the working groups
  • Excellent teamwork and communication skills

What we can offer

  • Regular pay according to TVöD/VKA; attractive company pension plan and various employee discounts
  • 30 days of vacation; possibility of special leave
  • Central location: Our clinic is centrally located at the beautiful Eppendorfer Park
  • Sustainable travel: subsidies for the HVV-ProfiTicket and Dr. Bike bicycle service; option to lease a service bike
  • Crisis-proof workplace, meaningful activity, appreciative interaction and open exchange of knowledge within the team; structured induction training
  • Opportunity to actively shape and develop the working environment within the framework of our employee program (UKE INside).
  • Family-friendly working environment: cooperation on childcare, free vacation care, advice for employees with relatives in need of care
  • Excellent health, prevention and sports offers
  • Healthy and varied lunch break: In addition to our canteen, there is a rich selection of culinary offerings just a few steps away, for example the "Health Kitchen" cafés and bistros, as well as other snack bars, bakers, a supermarket, etc.

The UKE

We are the UKE - and we stand for excellent competence in the areas of research, teaching and comprehensive health care in our clinics. Every day our 14.100 employees strive to make the world a little healthier by their contribution.

It is our aim to be one of the leading University Medical Centers and, at the same time, the best employer in our industry. At the UKE, we are convinced that successful and fulfilling work should be harmonised with the personal needs and individual life plans of all employees. And as different as these are, as diverse is our range of individual solutions.

Better together. For life.
Welcome to the UKE.


> Find out more about the UKE and our aspirations as an employer

Your application options at a glance

Choose the application method that suits you best.
You can send us your application quickly and easily - online, by email or by post. Alternatively, you can submit your application to our recruiting team in person.
> Click here to access information on the various application options

We live and value diversity
We offer a work environment providing equal opportunities regardless of age, gender, sexual identity, disability, origin or religion. This is affirmed by our accession to the Charter of Diversity.

We explicitly strive to increase the proportion of women in management positions, especially among scientific staff in research and teaching.

The same applies in case of an underrepresentation of one's gender in the advertising area. People with severe disabilities will be considered with priority in case of equal suitability, qualification and professional performance.
> Find out more about diversity at the UKE

Your Perspective

Hamburg and its UKE. As one of the largest employers in the Hanseatic city, we stand for excellent competence in the areas of research, teaching and comprehensive health care in our clinics. Every day our 14.100 employees strive to make the world a little healthier by their contribution.

With more than 140 different job profiles – in nursing, the various healthcare professions, in medical and medical-technical services or therapeutic and educational professions as well as in research and teaching up to a career in administration or in the technology and service area – we are the ideal place for everyone who wants to keep getting better with us.

Better together. For life.
Welcome to the UKE.


> Find out more about the different professions and prospects at the UKE here

Contact

Dr. Christine Dahlke (c.dahlke@uke.de)

Dr Wiebke Hartmann (hartmann@bnitm.de)

Please note that your application can only be considered if you are fully immunised against the SARS-CoV-2 virus (at the latest at the start of engagement), supported by valid official vaccination certificate(s). Please submit these with your application.

We look forward to receiving your complete application by 10.10.2022 stating reference code WS22759.

Please apply via BEWERBUNG@UKE.DE

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